Description
Sylimarol®
Silybum marianum (Milk Thistle)
50 mg tablet
NPN 80026050
30 or 60 tablets
Medicinal Ingredient (per tablet):
Silybum marianum, 50 mg
Non-Medicinal Ingredients:
dextrose, starch potato, saccharose, magnesium stearate, talc, gum arabic, beeswax – bleached, carnauba, FD&C Blue No. 2, quinoline yellow E 104.
Recommended Use: Oral:
Used in herbal medicine to help support liver function. It is used in convalescence after toxic-metabolic liver damage caused by, inter alia,toxic agents (e.g. alcohol, pesticides) and eating heavy meals. Used as supportive therapy for liver dysfunctions and chronic inflammation of the liver.
Directions for Use:
Adults: Take two (2) tablets 3 times daily after meals. The product requires systematic use, from a 4-week period in the case of intoxication to a 6-month therapy in chronic conditions. It is possible to increase the dose to 10 tablets daily after consulting a physician or in the case of severe intoxication. The minimum daily dose is 200 mg, and the maximum is 400 mg.
Contraindications:
Hypersensitivity to any ingredient or hypersensitivity to plants of the Compositae family.
Interactions with other medicinal products and other forms of interaction:
None reported.
Effects on ability to drive and use machines:
No effects on the ability to drive and use machines have been performed.
Overdose:
No case of overdose has been reported.
Known Adverse Reactions:
Hypersensitivity, such as an allergy, has been known to occur, in which case, discontinue use. There may be a mild laxative effect.
Keep this medicine out of the sight and reach of children. Do not use this medicine after the expiry date. Store at room temperature between 15°- 25° C.
Cautions and Warnings:
Consult a health care practitioner if symptoms persist. Consult a health care practitioner if symptoms worsen. Consult a health care practitioner prior to use if you are pregnant or
SYLIMAROL
Derivatives of milk thistle (Silybum marianum) have been used as herbal remedies for almost 2000 years. Their use has been widespread throughout Europe since preparations became officially available for clinical use there in 1969. At present milk thistle extracts account for over $180 million in sales annually in Germany(2), and natural remedies in general for $1.6 billion annually in the United States.(3) Sylimarin is a unique ingredient in Sylimarol. The flavonoid sylimarin and one of its structural components, silibinin, are substances with documented hepatoprotective properties.(1)
Milk Thistle is widely used to treat cirrrhosis, chronic liver disease, moderate alcohol-related liver disease. The flavonoids appear to be active as free radical scavengers and stabilizers of plasma membranes.(2)
For more serious conditions, such as mentioned above, daily dosage ranges from 280 to 800 mg. This is equivalent to 400 to 1140 mg of standarized extract containing 70% sylimarin(2)
NHP Ingredients Database Suggested dosage: Preparations equivalent to 140-600 mg sylimarin (calculated as silibinin/silybin), per day; not to exceed 200 mg per dose
SYLIMAROL comes in tablet’s strength of 50 mg of standarized extract containing 70% = 35mg of sylimarin. Advantage of such small dosage is that it can be used by healthy patients after eating heavy meals, drinking alkohol etc to help liver to clean itself from toxic substances contained in food.
Wast majority of sylimarin (milk thistle) products available on Candian market are coming in high dosages of 200 mg up to 600 mg (NHP database) There is only few products with small dosage as is in Sylimarol.
It is necessary to consult a physician with regards to all health matters.
(1.)Hebel, SK (ed) Facts and Comparisons. The review of Natural Products. St. Louis (MO): Wolters Kluwer Company; 1996
*K.Flora, M.D. et al, Milk Thistle (Silybum marianum) for the therapy of liver disease. The American Journal of Gastroeterology, 1998; 93: 139-43,.
. **Brevoort P. The U.S. botanical market – An overview. Herbalgram 1996; 36:49-57.
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